Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer
Kimmelman A, Hezel A, Aguirre A, Zheng H, Paik J, Ying H, Chu G, Zhang J, Sahin E, Yeo G, Ponugoti A, Nabioullin R, Deroo S, Yang S, Wang X, McGrath J, Protopopova M, Ivanova E, Zhang J, Feng B, Tsao M, Redston M, Protopopov A, Xiao Y, Futreal P, Hahn W, Klimstra D, Chin L, DePinho R. Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 19372-19377. PMID: 19050074, PMCID: PMC2614768, DOI: 10.1073/pnas.0809966105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, Pancreatic DuctalCell Line, TransformedCell MovementGene Expression Regulation, NeoplasticGenomicsHumansMiceMice, NudeNeoplasm Invasivenessp21-Activated KinasesPancreatic DuctsPancreatic NeoplasmsPhenotypeProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktrho GTP-Binding ProteinsSignal TransductionConceptsRIO kinase 3P21-activated kinase 4Amplified genesRho family GTP-binding proteinsRho family of GTPasesGenome wide surveyFamily of GTPasesSmall G proteinsGTP-binding proteinsRho familyRac signalingGenetic elementsCell motilityResident genesCytoskeletal architectureFocal amplificationGenomic instabilityInvasive phenotypePancreas ductal adenocarcinomaInvasive propensityGenomic alterationsCell migrationInvasive activityG-proteinRho
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