2018
Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone core formation in mice
Tanaka H, Imasato M, Yamazaki Y, Matsumoto K, Kunimoto K, Delpierre J, Meyer K, Zerial M, Kitamura N, Watanabe M, Tamura A, Tsukita S. Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone core formation in mice. Journal Of Hepatology 2018, 69: 1308-1316. PMID: 30213590, DOI: 10.1016/j.jhep.2018.08.025.Peer-Reviewed Original ResearchConceptsHepatic tight junctionsCholesterol gallstone diseaseGallstone diseaseAge-related riskParacellular barrierClaudin-3Cholesterol gallstonesParacellular permeability of ionsTight junctionsFormation of cholesterol gallstonesTight junction proteinsHepatobiliary epitheliaIn vivo evidenceParacellular permeabilityCholesterol gallstone formationJunction proteinsGallstonesHepatobiliary systemGallstone formationMiceCholesterolDiseaseCLDN3Ion metabolismMouse liver
1999
A Prospective Study of Coffee Consumption and the Risk of Symptomatic Gallstone Disease in Men
Leitzmann MF, Willett WC, Rimm EB, Stampfer MJ, Spiegelman D, Colditz GA, Giovannucci E. A Prospective Study of Coffee Consumption and the Risk of Symptomatic Gallstone Disease in Men. JAMA 1999, 281: 2106-2112. PMID: 10367821, DOI: 10.1001/jama.281.22.2106.Peer-Reviewed Original ResearchConceptsSymptomatic gallstone diseaseGallstone diseaseRelative riskCoffee consumptionDecreased riskRisk factorsCaffeine intakeHealth professionalsUS male health professionalsMale health professionalsRegular coffeeProspective cohort studyFood frequency questionnaireConsumption of coffeeCohort studyFrequency questionnaireProspective studyMore cupsMetabolic effectsUS menGallstone formationDecaffeinated coffeeDiseaseMenCholecystectomy
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