Template switching during DNA replication is a prevalent source of adaptive gene amplification
Chuong J, Ben Nun N, Suresh I, Matthews J, De T, Avecilla G, Abdul-Rahman F, Brandt N, Ram Y, Gresham D. Template switching during DNA replication is a prevalent source of adaptive gene amplification. ELife 2025, 13 DOI: 10.7554/elife.98934.3.Peer-Reviewed Original ResearchCopy number variantsGAP1 CNVsLong terminal repeatTemplate switchingDNA replicationDynamics of copy number variantsCNV formationEffect of copy number variantsOrigin of DNA replicationSource of genetic variationFitness effectsLocal DNA featuresGene amplificationGAP1 geneGenome architectureGenome evolutionGenomic elementsGenomic locationsDNA elementsSaccharomyces cerevisiaeAdaptive evolutionLagging strandEngineered strainGenetic variationHomologous recombination
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