Sucrose Formulated Recombinant Human Antihemophilic Factor VIII Is Safe and Efficacious for Treatment of Hemophilia A in Home Therapy
Abshire T, Brackmann H, Scharrer I, Hoots K, Gazengel C, Powell J, Gorina E, Kellermann E, Vosburgh E. Sucrose Formulated Recombinant Human Antihemophilic Factor VIII Is Safe and Efficacious for Treatment of Hemophilia A in Home Therapy. Thrombosis And Haemostasis 2000, 83: 811-816. PMID: 10896230, DOI: 10.1055/s-0037-1613925.Peer-Reviewed Original ResearchConceptsRFVIII-FSHome therapyAdverse eventsPharmacokinetic profileHemophilia ADrug-related adverse eventsRecombinant factor VIII productsIntermittent chest painFactor replacement therapyTreatment of bleedsSevere haemophilia AFirst clinical trialFactor VIII productsExcellent hemostatic controlSignificant adverse effectsFull-length rFVIIIChest painReplacement therapyClinical trialsViral inactivation stepsHemostatic controlExposure daysPatientsFactor VIIITherapy
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