2022
Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia
Zhang K, Horikoshi N, Li S, Powers A, Hameedi M, Pintilie G, Chae H, Khan Y, Suomivuori C, Dror R, Sakamoto K, Chiu W, Wakatsuki S. Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia. ACS Central Science 2022, 8: 214-222. PMID: 35233453, PMCID: PMC8875425, DOI: 10.1021/acscentsci.1c01090.Peer-Reviewed Original ResearchKIX domain of CREB-binding proteinCREB-binding proteinKIX domainDouble-shellMaltose-binding proteinCryo-EMHelix-helix interactionsMolecular dynamics simulationsCryo-EM analysisCryo-EM structureStructure-based inhibitor designStructure of proteinsMolecular therapeutic developmentAcute myeloid leukemiaFluorescence polarization assayPKID domainDevelopment of next-generation inhibitorsProtein engineeringInteracting peptidesKIXDevelopment of peptide therapeuticsDynamics simulationsCryogenic electron microscopyA-resolutionHuman diseases
2017
JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules
Newton AS, Deiana L, Puleo DE, Cisneros J, Cutrona KJ, Schlessinger J, Jorgensen WL. JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules. ACS Medicinal Chemistry Letters 2017, 8: 614-617. PMID: 28626520, PMCID: PMC5467202, DOI: 10.1021/acsmedchemlett.7b00154.Peer-Reviewed Original Research
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