Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia
Zhang K, Horikoshi N, Li S, Powers A, Hameedi M, Pintilie G, Chae H, Khan Y, Suomivuori C, Dror R, Sakamoto K, Chiu W, Wakatsuki S. Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia. ACS Central Science 2022, 8: 214-222. PMID: 35233453, PMCID: PMC8875425, DOI: 10.1021/acscentsci.1c01090.Peer-Reviewed Original ResearchKIX domain of CREB-binding proteinCREB-binding proteinKIX domainDouble-shellMaltose-binding proteinCryo-EMHelix-helix interactionsMolecular dynamics simulationsCryo-EM analysisCryo-EM structureStructure-based inhibitor designStructure of proteinsMolecular therapeutic developmentAcute myeloid leukemiaFluorescence polarization assayPKID domainDevelopment of next-generation inhibitorsProtein engineeringInteracting peptidesKIXDevelopment of peptide therapeuticsDynamics simulationsCryogenic electron microscopyA-resolutionHuman diseases
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