The Real‐World Ethics of Adaptive‐Design Clinical Trials
Bothwell LE, Kesselheim AS. The Real‐World Ethics of Adaptive‐Design Clinical Trials. The Hastings Center Report 2017, 47: 27-37. PMID: 29171051, DOI: 10.1002/hast.783.Peer-Reviewed Original ResearchConceptsClinical equipoisePrimary ethical concernsMedical researchEthical approachEthical argumentsEthical justificationTrial control armEthical concernsEthicsAdaptive design clinical trialsTheoretical equipoiseCritical principlesEquipoiseAllocation of subjectsInferior treatmentProduct sponsorsArgumentCritical assessmentConventional RCTsAdditional concernsUseful standardActual trialAdaptive trialsJustificationClaims
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