SLIT3 deficiency attenuates pressure overload-induced cardiac fibrosis and remodeling
Gong L, Wang S, Shen L, Liu C, Shenouda M, Li B, Liu X, Shaw J, Wineman A, Yang Y, Xiong D, Eichmann A, Evans SM, Weiss SJ, Si MS. SLIT3 deficiency attenuates pressure overload-induced cardiac fibrosis and remodeling. JCI Insight 2020, 5 PMID: 32644051, PMCID: PMC7406261, DOI: 10.1172/jci.insight.136852.Peer-Reviewed Original ResearchConceptsVentricular pressure overloadRight ventricular pressure overloadPressure overloadMyocardial fibrosisVentricular functionPressure overload-induced cardiac fibrosisLong-term ventricular functionOverload-induced cardiac fibrosisSlit guidance ligand 3Fibroblast activityPulmonary artery bandingPoor clinical outcomeTransverse aortic constrictionCongenital heart diseaseCollagen productionGlobal knockout micePotential therapeutic targetFibrillar collagen synthesisPulmonary hypertensionVentricular dysfunctionHemodynamic abnormalitiesOverall survivalAdverse remodelingClinical outcomesAfterload elevation
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply