2023
GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice
Yamamoto H, Lee-Okada H, Ikeda M, Nakamura T, Saito T, Takata A, Yokomizo T, Iwata N, Kato T, Kasahara T. GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice. Molecular Psychiatry 2023, 28: 2848-2856. PMID: 36806390, PMCID: PMC10615742, DOI: 10.1038/s41380-023-01988-2.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesFatty acid desaturaseLarge-scale genome-wide association studiesMutant miceFatty acid metabolismUnsaturated fatty acid metabolismAssociation studiesDocosahexaenoic acidGene regionHeterozygous mutant miceBipolar disorderEicosapentaenoic acidSusceptibility allelesRisk allelesShorter immobility timeBehavioral despair testAcid metabolismWild-typeAbnormal circadian rhythmTreatment of BDMood stabilizer lithiumModel of BDFADS1/2AllelesLipid composition
2013
Interaction of Fatty Acid Genotype and Diet on Changes in Colonic Fatty Acids in a Mediterranean Diet Intervention Study
Porenta S, Ko Y, Raskin L, Gruber S, Mukherjee B, Baylin A, Ren J, Djuric Z. Interaction of Fatty Acid Genotype and Diet on Changes in Colonic Fatty Acids in a Mediterranean Diet Intervention Study. Cancer Prevention Research 2013, 6: 1212-1221. PMID: 24022589, PMCID: PMC3840911, DOI: 10.1158/1940-6207.capr-13-0131.Peer-Reviewed Original ResearchConceptsFatty acid desaturaseHealthy Eating dietArachidonic acid concentrationIntake of n-3Fatty acid desaturase genotypeIncreased risk of colon cancerN-6 fatty acidsEating dietsIntake of n-6 fatty acidsRisk of colon cancerFatty acid desaturase gene clusterDietary fat intakeColon cancer riskSerum eicosapentaenoic acidDiet intervention studyInteraction of polymorphismsSerum arachidonic acidFatty acid desaturase geneFatty acidsSingle-nucleotide polymorphismsFat intakeN-3N-6Colon cancerAssociated with genotypeFADS genotype affects change in fatty acid levels after a Mediterranean dietary intervention
Djuric Z, Porenta S, Ren J, Ko Y, Baylin A, Mukherjee B, Gruber S. FADS genotype affects change in fatty acid levels after a Mediterranean dietary intervention. The FASEB Journal 2013, 27: 372.5-372.5. DOI: 10.1096/fasebj.27.1_supplement.372.5.Peer-Reviewed Original ResearchFatty acid levelsProstaglandin E2Allele carriersColonic mucosaFADS genotypesIntake of n-3Increased colon cancer riskIntake of n-6 fatty acidsMediterranean dietary interventionAcid levelsColon cancer riskMinor allele carriersSerum arachidonic acidFatty acidsFatty acid desaturaseN-6 fatty acid levelsPro-inflammatory eicosanoidsColon cancerDietary interventionFADS clusterN-9 fatty acidsCancer riskMediterranean dietLowered intakeN-6 fatty acids
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