GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice
Yamamoto H, Lee-Okada H, Ikeda M, Nakamura T, Saito T, Takata A, Yokomizo T, Iwata N, Kato T, Kasahara T. GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice. Molecular Psychiatry 2023, 28: 2848-2856. PMID: 36806390, PMCID: PMC10615742, DOI: 10.1038/s41380-023-01988-2.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesFatty acid desaturaseLarge-scale genome-wide association studiesMutant miceFatty acid metabolismUnsaturated fatty acid metabolismAssociation studiesDocosahexaenoic acidGene regionHeterozygous mutant miceBipolar disorderEicosapentaenoic acidSusceptibility allelesRisk allelesShorter immobility timeBehavioral despair testAcid metabolismWild-typeAbnormal circadian rhythmTreatment of BDMood stabilizer lithiumModel of BDFADS1/2AllelesLipid composition
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