2008
Resveratrol Inhibits Electrical Activity and Insulin Release from Insulinoma Cells by Block of Voltage-Gated Ca2+ Channels and Swelling-Dependent Cl- Currents
Jakab M, Lach S, Bacová Z, Langelüddecke C, Strbák V, Schmidt S, Iglseder E, Paulmichl M, Geibel J, Ritter M. Resveratrol Inhibits Electrical Activity and Insulin Release from Insulinoma Cells by Block of Voltage-Gated Ca2+ Channels and Swelling-Dependent Cl- Currents. Cellular Physiology And Biochemistry 2008, 22: 567-578. PMID: 19088439, DOI: 10.1159/000185541.Peer-Reviewed Original ResearchConceptsHigh extracellular glucoseElectrical activityInsulin releaseCl- currentBlock of VoltageWhole-cell patch-clamp experimentsPresence of iberiotoxinRat INS-1E cellsInsulinoma cellsMembrane depolarizationBasal insulin releaseGlucose-induced depolarizationExtracellular glucoseApplication of resveratrolCell membrane depolarizationPatch-clamp experimentsInsulin-secreting cellsINS-1E cellsInsulin secretionRV doseAnimal modelsSecreting cellsInsulin responsivenessClamp experimentsResveratrol
1998
Chronic hyperosmolality increases NHE3 activity in OKP cells.
Ambühl P, Amemiya M, Preisig PA, Moe OW, Alpern RJ. Chronic hyperosmolality increases NHE3 activity in OKP cells. Journal Of Clinical Investigation 1998, 101: 170-177. PMID: 9421479, PMCID: PMC508553, DOI: 10.1172/jci62.Peer-Reviewed Original ResearchConceptsNa/H exchanger 3Na/H antiporter activityDiabetes mellitusNHE3 mRNA abundanceNHE3 protein abundanceAntiporter activityChronic hypertonicityGlomerular hyperfiltrationDiabetic nephropathyNa/H antiporterChronic hyperosmolalityOKP cellsExchanger 3MOsm/NHE3 activityRelevant increaseMellitusSignificant increaseChronicH antiporterExtracellular glucoseHypertonic incubationMRNA abundanceHypertonicitySmall increase
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