2025
TX-Phase: Secure Phasing of Private Genomes in a Trusted Execution Environment
Dokmai N, Zhu K, Sahinalp S, Cho H. TX-Phase: Secure Phasing of Private Genomes in a Trusted Execution Environment. Lecture Notes In Computer Science 2025, 15647: 325-329. DOI: 10.1007/978-3-031-90252-9_32.Peer-Reviewed Original ResearchTrusted Execution EnvironmentExecution environmentData privacy concernsSide-channel leakageState-of-the-artExtract valuable insightsOpen-source softwarePrivate genomic dataFixed-point arithmeticData confidentialityPrivacy constraintsPrivacy concernsSecurity phaseAlgorithmic techniquesServerGenomic dataEnhanced accuracyPractical performanceImputation workflowAnalysis toolsDatasetPhase algorithmAccuracyPrivacyHaplotype phasingLearning-augmented sketching offers improved performance for privacy preserving and secure GWAS
Xu J, Zhu K, Cai J, Kockan C, Dokmai N, Cho H, Woodruff D, Sahinalp S. Learning-augmented sketching offers improved performance for privacy preserving and secure GWAS. IScience 2025, 28: 112011. PMID: 40124506, PMCID: PMC11927738, DOI: 10.1016/j.isci.2025.112011.Peer-Reviewed Original ResearchTrusted Execution EnvironmentGenome-wide association studiesPublic training datasetsComputational resource constraintsOptimize memory usageIntel SGXPrivacy guaranteesPrivacy preservationExecution environmentCloud providersMemory usageMemory constraintsTraining datasetDatasetResource constraintsHigher accuracyPrivacyDedicated memoryExperimental resultsImproved performanceSignificant SNPsGWA studiesAssociation studiesGenotype dataSNPs
2021
Privacy-preserving genotype imputation in a trusted execution environment
Dokmai N, Kockan C, Zhu K, Wang X, Sahinalp S, Cho H. Privacy-preserving genotype imputation in a trusted execution environment. Cell Systems 2021, 12: 983-993.e7. PMID: 34450045, PMCID: PMC8542641, DOI: 10.1016/j.cels.2021.08.001.Peer-Reviewed Original ResearchConceptsTrusted Execution EnvironmentExecution environmentHardware-based solutionsSide-channel attacksIntel SGXEnhanced securityPrivacy concernsAnalysis servicesImputation ServerServer limitData resourcesImputation algorithmSGXServerImputation softwareGenomic data resourcesImputation accuracyGenotype imputationImputation strategiesServicesDownstream analysisScalabilityImputationEssential toolSecurity
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