2005
Requirement for Tumor Necrosis Factor-Receptor 2 in Alveolar Chemokine Expression Depends upon the Form of the Ligand
Liu J, Zhao M, Xu L, Ramana C, Declercq W, Vandenabeele P, Enelow R. Requirement for Tumor Necrosis Factor-Receptor 2 in Alveolar Chemokine Expression Depends upon the Form of the Ligand. American Journal Of Respiratory Cell And Molecular Biology 2005, 33: 463-469. PMID: 16081883, DOI: 10.1165/rcmb.2005-0204oc.Peer-Reviewed Original ResearchConceptsCD8+ T cellsRespiratory virus infectionsT cellsTNF-R2TNF-alphaAntigen-specific CD8+ T cellsTNF receptorsCD8+ T lymphocytesTumor necrosis factor (TNF)-alphaVirus infectionExpression of TNF-R2Tumor necrosis factor receptor 2TNF receptor 1 expressionT cell responsesMonocyte chemoattractant protein (MCP)-1 expressionTNF-alpha activityEpithelial target cellsTransmembrane TNF-alphaSoluble TNF-alphaMCP-1 expressionBystander inflammationExperimental influenzaT lymphocytesChemokine expressionLung injury
2004
Perforin and Fas Ligand Are Required for the Regulation of Alloreactive CD8+ T Cells.
Maeda Y, Levy R, Reddy P, Liu C, Teshima T, Ferrara J. Perforin and Fas Ligand Are Required for the Regulation of Alloreactive CD8+ T Cells. Blood 2004, 104: 3052. DOI: 10.1182/blood.v104.11.3052.3052.Peer-Reviewed Original ResearchDonor T cellsT cellsDonor CD8WT T cellsAlloreactive CD8Day 10Day 30Host antigen presenting cellsFas ligandSingle MHC class IHost dendritic cellsModel of graftT cell populationsAntigen presenting cellsT cell homeostasisFas ligand pathwayMHC class IAllogeneic CD8Bm1 miceLethal GVHDSevere GVHDSignificant GVHDHost diseaseBMT recipientsEpithelial target cells
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