2024
B-Cell Epigenetic Modulation of IgA Response by 5-Azacytidine and IgA Nephropathy
Yu S, Li X, Wang T, Li J, Li H, Xu Y, Hu Y, Zhu F, Wang J, Wang T, Zhu B, Zhou X, Zhang H, Lv J, Barratt J, Zhao B. B-Cell Epigenetic Modulation of IgA Response by 5-Azacytidine and IgA Nephropathy. Journal Of The American Society Of Nephrology 2024, 35: 1686-1701. PMID: 39137052, PMCID: PMC11617474, DOI: 10.1681/asn.0000000000000441.Peer-Reviewed Original ResearchMiR-23bRNA 5-methylcytosineActivation-induced cytidine deaminase activityEpigenetic regulatory mechanismsRNA modificationsClass switch recombinationTreated with 5-azacytidineIgA class switchingDiseased miceEpigenetic mechanismsClass switchingDysregulation of IgA productionMethyltransferase 1IgA productionB cellsCytidine deaminase activityRegulatory mechanismsLactobacillus caseiSwitch recombinationDeaminase activityRNATRDMT1IgA class switch recombinationIgA synthesisPhenotype
2023
Characterization of the distribution and dynamics of chromatin states in the C. elegans germ line reveals substantial H3K4me3 remodeling during oogenesis
Mazzetto M, Gonzalez L, Sanchez N, Reinke V. Characterization of the distribution and dynamics of chromatin states in the C. elegans germ line reveals substantial H3K4me3 remodeling during oogenesis. Genome Research 2023, 34: gr.278247.123. PMID: 38164610, PMCID: PMC10903938, DOI: 10.1101/gr.278247.123.Peer-Reviewed Original ResearchEpigenetic regulatory mechanismsGerm lineChromatin stateGerm cellsC. elegans germ lineGene expressionRegulatory mechanismsDevelopmental transitionsActive histone modification H3K4me3Most genomic studiesZygotic genome activationSmall RNA pathwaysSpatio-temporal expression patternsHistone modifications H3K4me3Chromatin accessibility dataGerm cell differentiationOverall transcript abundanceUndifferentiated germ cellsGenome activationRNA pathwaysChromatin landscapeChromatin organizationChromatin structureEssential genesHistone modifications
2021
Evaluation of genome-wide DNA methylation profile of human embryos with different developmental competences
Yang M, Tao X, Scott K, Zhan Y, Scott RT, Seli E. Evaluation of genome-wide DNA methylation profile of human embryos with different developmental competences. Human Reproduction 2021, 36: 1682-1690. PMID: 33846747, DOI: 10.1093/humrep/deab074.Peer-Reviewed Original ResearchConceptsWhole-genome bisulfite sequencingDNA methylation profilesGenome-wide DNA methylation levelsGenome-wide DNA methylation profilesGenome-wide methylation levelsDNA methylation levelsMethylation profilesMethylation levelsDNA methylationGenome-wide DNA methylome analysisWhole-genome sequencing librariesDifferent DNA methylation profilesEpigenetic regulatory mechanismsDifferent developmental potentialEmbryonic competenceDNA methylome analysisPre-implantation embryo developmentInvolved chromosomeTrophectoderm biopsy samplesDifferentiation of cellsHuman preimplantation embryosCopy number varianceChromosomal scaleLower methylation levelsEmbryo identity
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