2024
B-Cell Epigenetic Modulation of IgA Response by 5-Azacytidine and IgA Nephropathy
Yu S, Li X, Wang T, Li J, Li H, Xu Y, Hu Y, Zhu F, Wang J, Wang T, Zhu B, Zhou X, Zhang H, Lv J, Barratt J, Zhao B. B-Cell Epigenetic Modulation of IgA Response by 5-Azacytidine and IgA Nephropathy. Journal Of The American Society Of Nephrology 2024, 35: 1686-1701. PMID: 39137052, PMCID: PMC11617474, DOI: 10.1681/asn.0000000000000441.Peer-Reviewed Original ResearchMiR-23bRNA 5-methylcytosineActivation-induced cytidine deaminase activityEpigenetic regulatory mechanismsRNA modificationsClass switch recombinationTreated with 5-azacytidineIgA class switchingDiseased miceEpigenetic mechanismsClass switchingDysregulation of IgA productionMethyltransferase 1IgA productionB cellsCytidine deaminase activityRegulatory mechanismsLactobacillus caseiSwitch recombinationDeaminase activityRNATRDMT1IgA class switch recombinationIgA synthesisPhenotype
2021
Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity
Hu W, Wang Z, Feng Y, Schizas M, Hoyos B, van der Veeken J, Verter J, Bou-Puerto R, Rudensky A. Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity. Nature Immunology 2021, 22: 1163-1174. PMID: 34426690, PMCID: PMC9341271, DOI: 10.1038/s41590-021-01001-4.Peer-Reviewed Original ResearchConceptsRegulatory T cellsTreg cellsFatal autoimmune diseaseSystemic inflammationAutoimmune diseasesT cellsPro-inflammatory effector cellsFatal autoimmune inflammationFOXP3 protein expressionSevere tissue inflammationTranscription factor Foxp3Autoimmune inflammationFatal autoimmunityInflammatory mediatorsEffector cellsImmune activationImmunosuppressive functionTissue inflammationDiseased miceImmune homeostasisInflammatory responseFactor Foxp3Long-term protectionInflammationLoss of function
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