2020
Structural Optimization of Polymeric Carriers to Enhance the Immunostimulatory Activity of Molecularly Defined RIG‑I Agonists
Jacobson ME, Becker KW, Palmer CR, Pastora LE, Fletcher RB, Collins KA, Fedorova O, Duvall CL, Pyle AM, Wilson JT. Structural Optimization of Polymeric Carriers to Enhance the Immunostimulatory Activity of Molecularly Defined RIG‑I Agonists. ACS Central Science 2020, 6: 2008-2022. PMID: 33274278, PMCID: PMC7706089, DOI: 10.1021/acscentsci.0c00568.Peer-Reviewed Original ResearchPolymeric carriersNew structure-activity relationshipsPH-responsive propertiesAlkyl methacrylate monomersIntracellular deliveryAlkyl chain lengthInefficient intracellular deliverySeries of PEGEndosomal escapeNovel polymeric carriersNucleic acid therapeuticsLead carrierStructure-activity relationshipsPolymer structureMethacrylate monomerPolymer compositionChain lengthPolymeric deliveryMonomer compositionPolymersMajor clearance organVariable compositionDiameter particlesMolecularlyCarriers
2002
Design of “Smart” polymers that can direct intracellular drug delivery
Hoffman A, Stayton P, Press O, Murthy N, Lackey C, Cheung C, Black F, Campbell J, Fausto N, Kyriakides T, Bornstein P. Design of “Smart” polymers that can direct intracellular drug delivery. Polymers For Advanced Technologies 2002, 13: 992-999. DOI: 10.1002/pat.232.Peer-Reviewed Original ResearchPH-sensitive polymerTypes of polymersEndosomal escapeBiomolecular drugsSynthetic polymersPolymeric biomaterialsBiological moleculesPeptide unitsPolymersBiomimetic propertiesEnvironmental signalsEndosomal membranesIntracellular traffickingMolecular mechanismsProtein coatGenetic materialBiological systemsEndosomesViral coatBondsAcidic pHSpecific peptidesInteresting modelLysosomal enzymesTrafficking
2001
Bioinspired polymers that control intracellular drug delivery
Hoffman A, Stayton P, Press O, Murthy N, Lackey C, Cheung C, Black F, Campbell J, Fausto N, Kyriakides T, Bornstein P. Bioinspired polymers that control intracellular drug delivery. Biotechnology And Bioprocess Engineering 2001, 6: 205-212. DOI: 10.1007/bf02931981.Peer-Reviewed Original ResearchPH-sensitive polymerIntracellular drug deliveryBioinspired polymersBiomimetic polymersBiomolecular drugsSynthetic polymersPolymeric biomaterialsBiological moleculesEnvironmental signalsPeptide unitsDrug deliveryPolymersEndosomal membranesBiomimetic propertiesMolecular mechanismsProtein coatViral coatEndosomal escapeBiological systemsInteresting modelSpecific peptidesEndosomesLysosomal enzymesCytoplasmPeptides
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