Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex
Kim S, Jeong J, Kim S, Seo W, Kim M, Choi W, Yoo W, Lee J, Shim Y, Yi H, Lee Y, Eun H, Lee B, Chun K, Kang S, Kim S, Gao B, Kunos G, Kim H, Jeong W. Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex. Nature Communications 2017, 8: 2247. PMID: 29269727, PMCID: PMC5740170, DOI: 10.1038/s41467-017-02325-2.Peer-Reviewed Original ResearchConceptsEndocytosis of TLR4Reactive oxygen speciesReactive oxygen species generationTLR4-MD2 complexDynamin-mediated endocytosisInhibition of dynaminHigh-fat diet-induced hepatic steatosisDiet-induced hepatic steatosisNADPH oxidaseTriggering endocytosisNon-alcoholic fatty liver diseaseEndocytosisROS generationDevelopment of non-alcoholic fatty liver diseaseFatty liver diseaseNADPH oxidase 2Oxygen speciesTLR4-MD2Toll-like receptor 4Multiple mechanismsTherapeutic targetNADPHHepatic steatosisInfiltrating MacrophagesDynamin
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