Physiologically Based Pharmacokinetic Model to Assess the Influence of Blinatumomab‐Mediated Cytokine Elevations on Cytochrome P450 Enzyme Activity
Xu Y, Hijazi Y, Wolf A, Wu B, Sun Y, Zhu M. Physiologically Based Pharmacokinetic Model to Assess the Influence of Blinatumomab‐Mediated Cytokine Elevations on Cytochrome P450 Enzyme Activity. CPT Pharmacometrics & Systems Pharmacology 2015, 4: 507-515. PMID: 26451330, PMCID: PMC4592530, DOI: 10.1002/psp4.12003.Peer-Reviewed Original ResearchElevation of cytokinesCytokine elevationCD19/CD3 bispecific T-cell engagerIL-6-mediated changesBispecific T-cell engagerIL-6T-cell engagersSuppression of CYP3A4Treatment of leukemiaSubstrates of CYP3A4Blinatumomab infusionCYP2C9 activityCytokine cocktailTransient elevationMagnitude of suppressionDrug interactionsCytochrome P450 enzyme activityCYP450 activityCytokinesPharmacokinetic modelHuman hepatocytesBlinatumomabPBPK modelCYP2C9Enzyme activity
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