2014
A functional screen for copper homeostasis genes identifies a pharmacologically tractable cellular system
Schlecht U, Suresh S, Xu W, Aparicio AM, Chu A, Proctor MJ, Davis RW, Scharfe C, St Onge RP. A functional screen for copper homeostasis genes identifies a pharmacologically tractable cellular system. BMC Genomics 2014, 15: 263. PMID: 24708151, PMCID: PMC4023593, DOI: 10.1186/1471-2164-15-263.Peer-Reviewed Original ResearchConceptsRespiratory growthFunctional screenCopper homeostasis genesHomozygous diploid deletionIntracellular copper concentrationList of genesComplex cellular systemsDeletion strainHomeostasis genesCopper homeostasisLow vacuolar pHDirect regulatorRespiratory defectsDifferent genesAerobic organismsIron uptakeFunctional linkMendelian disordersGenesCellular systemsGrowth mediumVacuolar pHHomeostasis resultsGenetic originHuman health
2013
Functional modulation of mitochondrial cytochrome c oxidase underlies adaptation to high-altitude hypoxia in a Tibetan migratory locust
Zhang ZY, Chen B, Zhao DJ, Kang L. Functional modulation of mitochondrial cytochrome c oxidase underlies adaptation to high-altitude hypoxia in a Tibetan migratory locust. Proceedings Of The Royal Society B 2013, 280: 20122758. PMID: 23390104, PMCID: PMC3574369, DOI: 10.1098/rspb.2012.2758.Peer-Reviewed Original ResearchConceptsCytochrome c oxidaseOxidative phosphorylationLocust populationsHypoxia responseMigratory locustHypoxia toleranceC oxidaseMitochondrial cytochrome c oxidaseElectron transport rateElevated catalytic efficiencyHigher hypoxia toleranceCatalytic redox centerHypoxia adaptationCOX activityMitochondrial structureAerobic organismsFlight musclesMitochondrial mechanismsNovel mechanismLocusta migratoriaLocustFunctional modulationPermanent hypoxiaHypoxic treatmentProtein content
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