2012
Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane
Sousa LP, Lax I, Shen H, Ferguson SM, De Camilli P, Schlessinger J. Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 4419-4424. PMID: 22371560, PMCID: PMC3311323, DOI: 10.1073/pnas.1200164109.Peer-Reviewed Original ResearchConceptsEGFR endocytosisPlasma membraneDynamin-mediated endocytosisEndocytosis of EGFRRole of endocytosisLow-affinity EGFRsEGF receptor activationCell surface receptorsMAPK responseMAPK stimulationEGFR degradationAkt stimulationCell signalingDynaminEGFR activationEGFR autophosphorylationAkt activationEndocytosisCell surfaceSurface receptorsMouse fibroblastsAkt responseReceptor activationHigh EGF concentrationsActivation
2010
Spatial control of EGF receptor activation by reversible dimerization on living cells
Chung I, Akita R, Vandlen R, Toomre D, Schlessinger J, Mellman I. Spatial control of EGF receptor activation by reversible dimerization on living cells. Nature 2010, 464: 783-787. PMID: 20208517, DOI: 10.1038/nature08827.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCell Line, TumorCell PolarityCell SurvivalCHO CellsCricetinaeCricetulusDiffusionEnzyme ActivationEnzyme StabilityEpidermal Growth FactorErbB ReceptorsGene Expression RegulationGRB2 Adaptor ProteinHumansKineticsLigandsProtein MultimerizationProtein TransportSignal TransductionThermodynamicsConceptsLigand bindingEpidermal growth factor receptor moleculeType I receptor kinaseEGF receptor activationDimer formationReceptor kinaseReceptor dimerizationDimerization dynamicsReceptor dimersLiving cellsReceptor moleculesCell marginsDimer populationSpatial controlHuman carcinomasConformation changeDimerizationCell centerReceptor activationRate of dissociationCellsBindingActivationKinaseReversible dimerization
2008
Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases
Yogev S, Schejter ED, Shilo B. Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases. The EMBO Journal 2008, 27: 1219-1230. PMID: 18369317, PMCID: PMC2367402, DOI: 10.1038/emboj.2008.58.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CompartmentationCell LineDrosophila melanogasterDrosophila ProteinsEndoplasmic ReticulumEpidermal Growth FactorErbB ReceptorsEye ProteinsGerm CellsHydrolysisIntracellular MembranesMembrane ProteinsProtein KinasesReceptors, Invertebrate Peptiderho GTP-Binding ProteinsSerine EndopeptidasesSignal TransductionConceptsLate compartmentsRho proteinsDifferential compartmentalizationEGFR activationRhomboid intramembrane proteasesEGF receptor activationAmount of chaperoneEGF receptor ligandsIntramembrane proteasesDrosophila EGFRSecretory pathwayGerm lineCompartment localizationSubsequent secretionProteinCompartmentalizationReceptor activationRho 3CompartmentsActivationChaperonesERProteasePathwayReceptor ligands
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