2024
T32. GENETIC ARCHITECTURE OF BIPOLAR SPECTRUM DISORDERS IN NEARLY 102,000 LATINO ANCESTRY INDIVIDUALS
Bigdeli T, Voloudakis G, Chatzinakos C, Barr P, Gorman B, Peterson R, Pyarajan S, Huang G, Gaziano M, Pato M, Fanous A, Pato C, Aslan M, Roussos P, Harvey P. T32. GENETIC ARCHITECTURE OF BIPOLAR SPECTRUM DISORDERS IN NEARLY 102,000 LATINO ANCESTRY INDIVIDUALS. European Neuropsychopharmacology 2024, 87: 173-174. DOI: 10.1016/j.euroneuro.2024.08.342.Peer-Reviewed Original ResearchGenome-wide association studiesPolygenic risk scoresEuropean ancestryMillion Veteran ProgramAdmixed AmericansGenomic Psychiatry CohortGenome-wide association study analysisGenome-wide significant signalsMulti-ancestry meta-analysisLocal ancestry inferenceStatistical fine-mappingBipolar disorderCooperative Studies ProgramGenomic structural equation modelingLatino individualsAncestry inferencePRS-CSxTrans-diagnostic approachBipolar spectrum disordersEast Asian populationsFine-mappingAssociation studiesGWAS statisticsPsychiatric genetic researchAncestry individualsA proteome‐wide analysis unveils a core Epstein–Barr virus antibody signature of classic Hodgkin lymphoma across ethnically diverse populations
Sarathkumara Y, Xian R, Liu Z, Yu K, Chan J, Kwong Y, Lam T, Liang R, Chiu B, Xu J, Hu W, Ji B, Coghill A, Kelly A, Pfeiffer R, Rothman N, Ambinder R, Hildesheim A, Lan Q, Proietti C, Doolan D. A proteome‐wide analysis unveils a core Epstein–Barr virus antibody signature of classic Hodgkin lymphoma across ethnically diverse populations. International Journal Of Cancer 2024, 155: 1476-1486. PMID: 38995124, PMCID: PMC11326961, DOI: 10.1002/ijc.35072.Peer-Reviewed Original ResearchEBV-positive cHLEpstein-Barr virusAntibody signaturesCase-control studyHodgkin lymphomaHumoral immune response to EBVEBV gene expression patternsImmune response to EBVAntibody responseHospital-based case-control studyResponse to EBVEast Asian populationsIgG antibodiesEpstein-Barr virus antibodiesClassical Hodgkin lymphomaAnti-EBV IgG antibodyMatched healthy controlsCHL patientsEBV antibodiesEBV proteinsHealthy controlsCustom protein microarrayPotential biomarkersEthnically diverse populationsAntibodies
2023
88. GENETIC ARCHITECTURE OF SCHIZOPHRENIA IN AFRICAN ANCESTRY INDIVIDUALS
Bigdeli T, Gorman B, Voloudakis G, Chatzinakos C, Barr P, Burstein D, Genovese G, Pyarajan S, Huang G, Pato C, Pato M, Fanous A, Aslan M, Harvey P, Roussos P. 88. GENETIC ARCHITECTURE OF SCHIZOPHRENIA IN AFRICAN ANCESTRY INDIVIDUALS. European Neuropsychopharmacology 2023, 75: s103. DOI: 10.1016/j.euroneuro.2023.08.191.Peer-Reviewed Original ResearchAfrican ancestry individualsAllelic effectsMillion Veteran ProgramFine-mapping resolutionGenome-wide significanceNew biological insightsDuplication eventsGenetic architectureGenomic methodologiesAncestry tractsIndex SNPsSingle locusPhenotypic dataGenetic analysisBiological insightsMHC lociAfrican diaspora populationsAfrican ancestryLociChromosome 6p21Genetic effectsGenetic researchEast Asian populationsLarge-scale research initiativesHuman population
2015
Ancestry informative markers for distinguishing between Thai populations based on genome-wide association datasets
Vongpaisarnsin K, Listman JB, Malison RT, Gelernter J. Ancestry informative markers for distinguishing between Thai populations based on genome-wide association datasets. Legal Medicine 2015, 17: 245-250. PMID: 25759192, PMCID: PMC4480199, DOI: 10.1016/j.legalmed.2015.02.004.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAncestry informative markersAssociation studiesGenome-wide association datasetInformative markersGenetic structureHapMap populationsSNP dataInternational HapMap databaseSuch SNPsEast Asian populationsHapMap databaseSNPsMarkersPopulationDiversityAsian populationsEfficient strategyThai population
2013
An historical perspective on “The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus”
Kidd KK, Pakstis AJ, Yun L. An historical perspective on “The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus”. Human Genetics 2013, 133: 431-433. PMID: 24162668, DOI: 10.1007/s00439-013-1386-0.Peer-Reviewed Original ResearchConceptsThousands of lociGene frequency patternsPatterns of divergenceRandom genetic driftHuman population geneticsLow-frequency allelesDopamine D4 receptor locusGenetic driftPopulation geneticsImportant genesPopulation variationWorld-wide distributionReceptor locusFrequency allelesDifferent allelesLociDistinct populationsNative American populationsEast Asian populationsAllelesAllele frequenciesSame populationAmerican populationGenesGenetics
2011
Diversification of the ADH1B Gene during Expansion of Modern Humans
Li H, Gu S, Han Y, Xu Z, Pakstis AJ, Jin L, Kidd JR, Kidd KK. Diversification of the ADH1B Gene during Expansion of Modern Humans. Annals Of Human Genetics 2011, 75: 497-507. PMID: 21592108, PMCID: PMC3722864, DOI: 10.1111/j.1469-1809.2011.00651.x.Peer-Reviewed Original ResearchConceptsShort tandem repeat polymorphismsSingle nucleotide polymorphismsGeographic patternsAncient DNA samplesADH1B geneSelective forcesRegulatory region variantsUnusual geographic distributionMigration eventsCommon haplogroupsDistinct geographic patternsGeographic distributionGenesNucleotide polymorphismsEast Asian populationsTandem repeat polymorphismDNA samplesHaplogroupsWorldwide setAllelesModern humansRegion variantsRepeat polymorphismPolymorphismEast Asia
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