2025
Head-to-Head comparison of [18F]FDG, [18F]FMZ, and [18F]SynVesT-1 positron emission tomography imaging in patients with drug-resistant epilepsy
Li G, Lin Z, Bao W, Jiang S, Wang J, Huang Q, Yang Y, He J, Huang Y, Guan Y, Hu J, Xie F. Head-to-Head comparison of [18F]FDG, [18F]FMZ, and [18F]SynVesT-1 positron emission tomography imaging in patients with drug-resistant epilepsy. European Journal Of Nuclear Medicine And Molecular Imaging 2025, 52: 2258-2266. PMID: 39888422, DOI: 10.1007/s00259-025-07111-7.Peer-Reviewed Original ResearchConceptsDrug-resistant epilepsyHypo-intense areaAge of epilepsy onsetEpilepsy onsetDysfunction of GABAergic neuronsPET imagingDrug-resistant epilepsy patientsGABAA receptor densityHead-to-head comparisonsAnatomical Automatic LabelingPositron emission tomography imagingVoxel numberEmission Tomography ImagingMethodsEleven patientsGABAergic neuronsReceptor abnormalitiesReceptor densityHypometabolic regionsPurposeThe lossPatientsGlycoprotein 2Tomography imagesGABAAVoxel-level analysisBrain regions
2023
A multicenter retrospective study of patients treated in the thalamus with responsive neurostimulation
Fields M, Eka O, Schreckinger C, Dugan P, Asaad W, Blum A, Bullinger K, Willie J, Burdette D, Anderson C, Quraishi I, Gerrard J, Singh A, Lee K, Yoo J, Ghatan S, Panov F, Marcuse L. A multicenter retrospective study of patients treated in the thalamus with responsive neurostimulation. Frontiers In Neurology 2023, 14: 1202631. PMID: 37745648, PMCID: PMC10516547, DOI: 10.3389/fneur.2023.1202631.Peer-Reviewed Original ResearchAnterior thalamic nucleiSerious adverse eventsGlobal Clinical Impression ScaleVagal nerve stimulationDrug-resistant epilepsyDeep brain stimulationAdverse eventsMost patientsResponsive neurostimulationSeizure reductionResective surgeryResistant epilepsyImpression ScaleSide effectsMedian baseline seizure frequencyDrug-resistant epilepsy patientsRare serious adverse eventsAnti-seizure medicationsDifferent epilepsy centersMeaningful seizure reductionMedian seizure reductionMedication regimen changesBaseline seizure frequencyMulticenter retrospective studyRetrospective multicenter study
2020
The Sensitivity of Scalp EEG at Detecting Seizures—A Simultaneous Scalp and Stereo EEG Study
Casale M, Marcuse L, Young J, Jette N, Panov F, Bender H, Saad A, Ghotra R, Ghatan S, Singh A, Yoo J, Fields M. The Sensitivity of Scalp EEG at Detecting Seizures—A Simultaneous Scalp and Stereo EEG Study. Journal Of Clinical Neurophysiology 2020, 39: 78-84. PMID: 32925173, PMCID: PMC8290181, DOI: 10.1097/wnp.0000000000000739.Peer-Reviewed Original ResearchConceptsBilateral tonic-clonic seizuresTonic-clonic seizuresSEEG seizuresMRI lesionsSubclinical seizuresScalp EEGDrug-resistant epilepsy patientsStereo-EEG studyStereo-EEG recordingsSimultaneous scalp EEGDetection of FocalNonlesional patientsInterictal abnormalitiesIctal patternsEpilepsy patientsLong-term effectsSeizuresPatientsSimultaneous scalpEEG seizuresScalpAbnormalitiesLonger durationEEG studiesLesions
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