Reticulocalbin-2 enhances hepatocellular carcinoma proliferation via modulating the EGFR-ERK pathway
Ding D, Huang H, Jiang W, Yu W, Zhu H, Liu J, Saiyin H, Wu J, Huang H, Jiang S, Yu L. Reticulocalbin-2 enhances hepatocellular carcinoma proliferation via modulating the EGFR-ERK pathway. Oncogene 2017, 36: 6691-6700. PMID: 28745317, DOI: 10.1038/onc.2017.230.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsCalcium-Binding ProteinsCarcinoma, HepatocellularCell Line, TumorCell ProliferationCell SurvivalErbB ReceptorsFemaleHumansLiver NeoplasmsMaleMAP Kinase Signaling SystemMice, NudeMiddle AgedNeoplasm TransplantationProtein Kinase InhibitorsProtein MultimerizationTumor BurdenConceptsEpidermal growth factor receptorEGFR-ERK pathwayHepatocellular carcinomaEGFR-ERKReticulocalbin-2Tumor growthCell proliferationDownregulated cyclin D1 expressionEpidermal growth factor receptor phosphorylationTherapeutic target of hepatocellular carcinomaKi-67 expressionTyrosine kinase inhibitorsG1/S transition arrestHepatocellular carcinoma patientsTargeting of hepatocellular carcinomaGrowth factor receptorExposure to EGFCyclin D1 expressionDisease recurrenceTumor sizeNon-tumor tissuesHepatocellular carcinoma cellsKi-67RCN2 expressionHCC cell proliferation
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