Mitochondrial DNA somatic mutation burden and heteroplasmy are associated with chronological age, smoking, and HIV infection
Ziada AS, Lu MY, Ignas‐Menzies J, Paintsil E, Li M, Ogbuagu O, Saberi S, Hsieh AYY, Sattha B, Harrigan PR, Kalloger S, Côté HCF, Pick N, Murray M, Money D, Soudeyns H, Kakkar F, Bitnun A, Brophy J, Janssen P, Singer J, Lapointe N, Prior J, Silverman M, Smith M, Macdonald H. Mitochondrial DNA somatic mutation burden and heteroplasmy are associated with chronological age, smoking, and HIV infection. Aging Cell 2019, 18: e13018. PMID: 31407474, PMCID: PMC6826146, DOI: 10.1111/acel.13018.Peer-Reviewed Original ResearchConceptsHIV infectionSomatic mutationsMtDNA mutationsOxidative damageSomatic mutation burdenHIV viremiaTobacco smokingMutation burdenSmokingMtDNA point mutationsDNA oxidative damageDe novo mutationsMitochondrial DNA mutationsInfectionNext-generation sequencingAgeSmokersRecent reportsSomatic mtDNA mutationsPrimer IDNovo mutationsLow-frequency mutationsChronological ageHeteroplasmic mutationsDNA mutations
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