2022
Cyclobutane Pyrimidine Dimer Hyperhotspots as Sensitive Indicators of Keratinocyte UV Exposure†
Garcia‐Ruiz A, Kornacker K, Brash DE. Cyclobutane Pyrimidine Dimer Hyperhotspots as Sensitive Indicators of Keratinocyte UV Exposure†. Photochemistry And Photobiology 2022, 98: 987-997. PMID: 35944237, PMCID: PMC9802031, DOI: 10.1111/php.13683.Peer-Reviewed Original ResearchConceptsCyclobutane pyrimidine dimersGenomic averageSequence motifsHigh-throughput DNA sequencing methodsETS family transcription factorsNucleotide resolution analysisRNA processing genesNeonatal human epidermal keratinocytesDNA sequencing methodsTranscription factorsCpG islandsSites hundredsCell physiologyProcessing genesPromoter regionCell deathDNA damageSequencing methodsBiological importanceHuman epidermal keratinocytesPyrimidine dimersGenesMotifEpidermal keratinocytesMelanocytes
2012
Molecular diagnostic testing for Klinefelter syndrome and other male sex chromosome aneuploidies
Hager K, Jennings K, Hosono S, Howell S, Gruen JR, Rivkees SA, Tartaglia NR, Rinder HM. Molecular diagnostic testing for Klinefelter syndrome and other male sex chromosome aneuploidies. International Journal Of Pediatric Endocrinology 2012, 2012: 8. PMID: 22524164, PMCID: PMC3411476, DOI: 10.1186/1687-9856-2012-8.Peer-Reviewed Original ResearchSex chromosome aneuploidyChromosome aneuploidyEarly mitotic divisionsHigh-throughput potentialAutosome ratiosDNA sequencing methodsBiallelic SNPsX chromosomeMolecular diagnostic assaysMitotic divisionGenomic DNASequencing methodsMarker dataDiagnostic assaysBuccal swab samplesPCR productsPyrosequencingKaryotypeAneuploidyDNANormal samplesMolecular diagnostic testingAssaysChromosomesMarkers
2009
Efficient yeast ChIP-Seq using multiplex short-read DNA sequencing
Lefrançois P, Euskirchen GM, Auerbach RK, Rozowsky J, Gibson T, Yellman CM, Gerstein M, Snyder M. Efficient yeast ChIP-Seq using multiplex short-read DNA sequencing. BMC Genomics 2009, 10: 37. PMID: 19159457, PMCID: PMC2656530, DOI: 10.1186/1471-2164-10-37.Peer-Reviewed Original ResearchConceptsChIP-seqTranscription factorsSequencing technologiesHigh-throughput DNA sequencing technologiesHigh-throughput sequencing technologyChIP-seq methodMammalian cell linesDNA sequencing technologiesLarge consortium projectsYeast centromeresSmall genomesChromosomal distributionYeast genomeModel organismsDNA sequencing methodsPol IIS. cerevisiaeBiological questionsYeast DNABarcoding systemIllumina platformCse4Low throughputSame DNA samplesHigh throughput
1978
Conservation of the primary structure at the 3′ end of 18S rRNA from eucaryotic cells
Hagenbüchle O, Santer M, Steitz J, Mans R. Conservation of the primary structure at the 3′ end of 18S rRNA from eucaryotic cells. Cell 1978, 13: 551-563. PMID: 77738, DOI: 10.1016/0092-8674(78)90328-8.Peer-Reviewed Original ResearchConceptsE. coli 16S rRNAE. coli ribosomesPurine-rich regionDNA sequencing methodsRRNA moleculesEucaryotic speciesStrong homologyCDNA transcriptsCDNA copyPolynucleotidyl transferasesRNA moleculesRRNA sequencesEucaryotic cellsEucaryotic mRNAsExtensive complementarityColi ribosomesRRNAPrimary structureEnzyme ATPSequencing methodsOligonucleotide primersAMV reverse transcriptaseTerminusReverse transcriptaseSequence
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply