2019
Endothelial Cell–Derived Interleukin-18 Released During Ischemia Reperfusion Injury Selectively Expands T Peripheral Helper Cells to Promote Alloantibody Production
Liu L, Fang C, Fu W, Jiang B, Li G, Qin L, Rosenbluth J, Gong G, Xie CB, Yoo P, Tellides G, Pober JS, Jane-Wit D. Endothelial Cell–Derived Interleukin-18 Released During Ischemia Reperfusion Injury Selectively Expands T Peripheral Helper Cells to Promote Alloantibody Production. Circulation 2019, 141: 464-478. PMID: 31744330, PMCID: PMC7035199, DOI: 10.1161/circulationaha.119.042501.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDelayed Graft FunctionFemaleGene Expression RegulationHuman Umbilical Vein Endothelial CellsHumansImmunoglobulin MInflammasomesInterleukin-18Interleukin-18 Receptor alpha SubunitIsoantibodiesMiceMice, SCIDOrgan TransplantationReperfusion InjurySignal TransductionT-Lymphocytes, Helper-InducerConceptsIschemia-reperfusion injuryDonor-specific antibodiesPeripheral helper cellsIL-18Helper cellsReperfusion injuryInterleukin-18IL-18R1Donor-specific antibody formationEndothelial cellsDelayed graft functionLate allograft lossT cell populationsAlloantibody productionAllograft lossChronic rejectionGraft functionClinical manifestationsPD-L2Antibody formationHumanized modelAllograft tissueImmunoglobulin MPatient specimensComplement activation
2015
Pathologic sequelae of allosensitization in liver transplantation
Zimmerman M, Schiller J, Kim J, Martin A, Selim M, Nydam T, Cronin D, Hong J. Pathologic sequelae of allosensitization in liver transplantation. Journal Of Surgical Research 2015, 200: 195-199. PMID: 26253457, DOI: 10.1016/j.jss.2015.06.047.Peer-Reviewed Original ResearchConceptsAntibody-mediated rejectionLiver transplantationImmune-mediated graft dysfunctionDonor-specific antibody formationPathological sequelaeImpact of allosensitizationAssociated with poor outcomesGraft dysfunctionGraft lossDonor/recipient pairsGraft pathologyPoor outcomeClinical evidenceAllosensitizationAntibody formationPathological injuryTransplantationGraftLiver
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