2024
HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration
Jang S, Bedwell G, Singh S, Yu H, Arnarson B, Singh P, Radhakrishnan R, Douglas A, Ingram Z, Freniere C, Akkermans O, Sarafianos S, Ambrose Z, Xiong Y, Anekal P, Llopis P, KewalRamani V, Francis A, Engelman A. HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration. Nucleic Acids Research 2024, 52: 11060-11082. PMID: 39258548, PMCID: PMC11472059, DOI: 10.1093/nar/gkae769.Peer-Reviewed Original ResearchConceptsHIV-1 infectionHIV-1Viral DNA integrationCPSF6 knockout cellsActivity in vitroHIV-1 pathogenesisHIV-1 integrationDNA integrityLiquid-liquid phase separationViral infectionNuclear specklesInfectionCapsids in vitroCPSF6NS depletionNuclear entryCapsid bindingCapsid-binding proteinKnockout cellsBinding proteinSR proteinsNuclear rimCo-aggregationDisordered regionsSperm Chromatin Structure Analysis and Clinical Correlations
Vaughan D, Sakkas D. Sperm Chromatin Structure Analysis and Clinical Correlations. 2024 DOI: 10.1016/b978-0-443-21477-6.00048-1.Peer-Reviewed Original Research
2023
Characterization of the HLA-F ligandome in T-cell lymphoma
Mota I, Osean J, Song E, Clement C, Lenz J, Miller D, Inghirami G, Montagna C, Bouvier M, Iwasaki A, Santambrogio L. Characterization of the HLA-F ligandome in T-cell lymphoma. The Journal Of Immunology 2023, 210: 222.06-222.06. DOI: 10.4049/jimmunol.210.supp.222.06.Peer-Reviewed Original ResearchT-cell lymphoma cell linesHealthy donor PBMCsT cellsLymphoma cell linesHLA-FDonor PBMCsTumor-specific antigensCancer immune responseT-cell lymphomaTotal T cellsNK cell receptorsTumor-specific markersCell linesHLA-I moleculesPeptides to T cellsCancer immunotherapyNK cellsHLA haplotypesRegulating immunityTherapeutic targetPotential new classDNA integrityDNA methylation patternsPeptide repertoirePBMC
2018
The safe use of Doliocarpus dentatus in the gestational period: Absence of changes in maternal reproductive performance, embryo-fetal development and DNA integrity
Ishikawa R, Vani J, das Neves S, Rabacow A, Kassuya C, Croda J, Cardoso C, Monreal A, Antoniolli A, Cunha-Laura A, Oliveira R. The safe use of Doliocarpus dentatus in the gestational period: Absence of changes in maternal reproductive performance, embryo-fetal development and DNA integrity. Journal Of Ethnopharmacology 2018, 217: 1-6. PMID: 29408581, DOI: 10.1016/j.jep.2018.01.034.Peer-Reviewed Original ResearchConceptsFemale Swiss miceDoliocarpus dentatusSwiss miceEmbryofetal developmentGestational periodControl groupPregnant female Swiss miceEnd of pregnancyEmbryo-fetal developmentMaternal reproductive performanceReproductive performanceSafe useEmbryofoetal developmentUrinary retentionOral gavageAbsence of changesDNA integrityAntimycobacterial actionFetal developmentReproductive parametersFormation of micronucleiEthanolic extractPregnancySignificant differencesExperimental group
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