2018
Investigating the Role of the BRCA2 C‐Terminus in Homologous Recombination
Chiang A, Ladino N, Lee K, Lu A, Srikanth N, Stearns W, Wen C, Williams S, Jensen R, D'Ausilio M. Investigating the Role of the BRCA2 C‐Terminus in Homologous Recombination. The FASEB Journal 2018, 32: lb211-lb211. DOI: 10.1096/fasebj.2018.32.1_supplement.lb211.Peer-Reviewed Original ResearchReplication protein ABRCA2 C terminusSingle stranded DNAHomologous recombinationC-terminusDouble strand break repairDNA double strand break repairRepair of damaged DNANucleoprotein filament formationTumor suppressor proteinC-terminus of BRCA2Strand break repairBinding to DNARAD51 bindingStructure-function relationshipsSuppressor proteinBreak repairDNA mimicsHR efficiencyDNA repairDSS1Damaged DNAFilament formationBRCA2BRCA2 mutations
2015
Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry
Zhao W, Vaithiyalingam S, San Filippo J, Maranon DG, Jimenez-Sainz J, Fontenay GV, Kwon Y, Leung SG, Lu L, Jensen RB, Chazin WJ, Wiese C, Sung P. Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry. Molecular Cell 2015, 59: 176-187. PMID: 26145171, PMCID: PMC4506714, DOI: 10.1016/j.molcel.2015.05.032.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionBRCA2 ProteinBreast NeoplasmsCell LineFemaleHeLa CellsHomologous RecombinationHumansModels, BiologicalMolecular MimicryMutagenesis, Site-DirectedNuclear Magnetic Resonance, BiomolecularProteasome Endopeptidase ComplexProtein SubunitsRad51 RecombinaseRecombinant ProteinsReplication Protein AConceptsReplication protein AHomologous recombinationAffinity of RPAReplication fork repairTumor suppressor BRCA2DNA mimicryGenome maintenanceFork repairMediator complexRAD51 recombinaseAcidic domainDNA breaksBiological processesTumor suppressionDSS1Vivo analysisProtein ADNA mimicsSsDNARecombinationBRCA2ComplexesRecombinaseDNAMutations
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