Investigating the Role of the BRCA2 C‐Terminus in Homologous Recombination
Chiang A, Ladino N, Lee K, Lu A, Srikanth N, Stearns W, Wen C, Williams S, Jensen R, D'Ausilio M. Investigating the Role of the BRCA2 C‐Terminus in Homologous Recombination. The FASEB Journal 2018, 32: lb211-lb211. DOI: 10.1096/fasebj.2018.32.1_supplement.lb211.Peer-Reviewed Original ResearchReplication protein ABRCA2 C terminusSingle stranded DNAHomologous recombinationC-terminusDouble strand break repairDNA double strand break repairRepair of damaged DNANucleoprotein filament formationTumor suppressor proteinC-terminus of BRCA2Strand break repairBinding to DNARAD51 bindingStructure-function relationshipsSuppressor proteinBreak repairDNA mimicsHR efficiencyDNA repairDSS1Damaged DNAFilament formationBRCA2BRCA2 mutations
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