Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response
Levine L, Hiam-Galvez K, Marquez D, Tenvooren I, Madden M, Contreras D, Dahunsi D, Irish J, Oluwole O, Rathmell J, Spitzer M. Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response. Immunity 2021, 54: 829-844.e5. PMID: 33705706, PMCID: PMC8046726, DOI: 10.1016/j.immuni.2021.02.018.Peer-Reviewed Original ResearchConceptsImmune responseMetabolic stateMass cytometrySingle-cell metabolic analysisSingle-cell resolutionChimeric antigen receptor TDistinct metabolic statesSingle-cell analysisAdvanced lymphoma patientsMetabolic protein expressionListeria monocytogenes infectionImmune cell populationsPrimary immune responseMetabolic proteinsCell signalingOxidative phosphorylationMetabolic regulationLymphoma patientsMemory TMonocytogenes infectionEffector TMetabolic regulatorMetabolic analysisMetabolic adaptationEffector functions
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