2021
Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24
Cao X, Khitun A, Luo Y, Na Z, Phoodokmai T, Sappakhaw K, Olatunji E, Uttamapinant C, Slavoff SA. Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24. Nature Communications 2021, 12: 508. PMID: 33479206, PMCID: PMC7820019, DOI: 10.1038/s41467-020-20841-6.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingAmino Acid SequenceBase SequenceBiological TransportCell MembraneDown-RegulationEndoplasmic ReticulumHEK293 CellsHumansMembrane ProteinsMutationPhosphatidylinositol 3-KinasesPhosphatidylinositol 4,5-DiphosphateProtein BindingProto-Oncogene Proteins c-aktRibosomal ProteinsSignal TransductionTOR Serine-Threonine KinasesConceptsPI3K-AktEndoplasmic reticulumMTOR signalingHuman gene functionAlternative open reading framesOpen reading framePI3K signalingDifferent molecular mechanismsCanonical proteinsGene functionCell sizeReading framePrecursor phosphatidylinositolPlasma membraneTMEM24Upstream regulatorMolecular mechanismsPhosphoserine residuesK signalingPoint mutationsSignalingPhosphatidylinositolProteinReticulumRPL36
2013
Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis
Vasanthakumar A, Lepore JB, Zegarek MH, Kocherginsky M, Singh M, Davis EM, Link PA, Anastasi J, Le Beau MM, Karpf AR, Godley LA. Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis. Blood 2013, 121: 2059-2063. PMID: 23315164, PMCID: PMC3596965, DOI: 10.1182/blood-2012-04-421065.Peer-Reviewed Original ResearchConceptsHaploinsufficient tumor suppressor geneTumor suppressor geneDNA methylationDe novo DNA methyltransferasesSuppressor geneNovo DNA methyltransferasesExpression of DNMT3B7Abnormal DNA methylationDominant negative isoformDifferent molecular mechanismsDNMT3B isoformsDNA methyltransferasesDNA hypermethylationDNMT3B geneAberrant splicingMolecular mechanismsTumor suppressorAbnormal transcriptsMYC/Human cancersGenesDNMT3B7DNMT3BMethylationMYC
2012
Network‐Assisted Investigation of Antipsychotic Drugs and Their Targets
Sun J, Xu H, Zhao Z. Network‐Assisted Investigation of Antipsychotic Drugs and Their Targets. Chemistry & Biodiversity 2012, 9: 900-910. PMID: 22589091, DOI: 10.1002/cbdv.201100356.Peer-Reviewed Original ResearchConceptsAdverse drug interactionsAntipsychotic drugsDrug interactionsDrug actionAtypical antipsychotic drugsTreatment of schizophreniaSevere mental disordersMolecular mechanismsPsychiatric medicationsReceptor profileMental disordersAntipsychoticsDrug-gene networkDrugsMolecular actionsDifferent molecular mechanismsDrugBank database
2011
Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats
Gracheva EO, Cordero-Morales JF, González-Carcacía JA, Ingolia NT, Manno C, Aranguren CI, Weissman JS, Julius D. Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats. Nature 2011, 476: 88-91. PMID: 21814281, PMCID: PMC3535012, DOI: 10.1038/nature10245.Peer-Reviewed Original ResearchConceptsVampire batsGene sequencesWarm-blooded preyGroup of snakesDifferent molecular mechanismsVertebrate lineageRNA splicingMolecular dataSensitive ion channelsMolecular mechanismsIon channelsBatsHeat-sensitive channelSplicingPit organsSnakesLineagesPreySequenceHot spotsDolphinsUnderliesRodentsVariants
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