2025
Drosophila Modulo is essential for transposon silencing and developmental robustness
Parikh R, Nayak D, Lin H, Gangaraju V. Drosophila Modulo is essential for transposon silencing and developmental robustness. Journal Of Biological Chemistry 2025, 301: 108210. PMID: 39848495, PMCID: PMC11879677, DOI: 10.1016/j.jbc.2025.108210.Peer-Reviewed Original ResearchPIWI-interacting RNAsTransposable elementsDevelopmental robustnessTE silencingSilencing of transposable elementsP-element induced wimpy testisPreserving genome integrityHistone 3 lysineIntrinsic genetic variationPost-transcriptional silencingMammalian nucleolinTransposon RNAsTransposon silencingPiRNA functionPiwi-piRNATE activityGenomic sitesMaternal germlineArgonaute 3Genome integrityTranscriptional silencingGenetic variationEpigenetic regulationPiwiBinding protein
2022
Transcription factor antagonism regulates heterogeneity in embryonic stem cell states
Hu S, Metcalf E, Mahat D, Chan L, Sohal N, Chakraborty M, Hamilton M, Singh A, Singh A, Lees J, Sharp P, Garg S. Transcription factor antagonism regulates heterogeneity in embryonic stem cell states. Molecular Cell 2022, 82: 4410-4427.e12. PMID: 36356583, PMCID: PMC9722640, DOI: 10.1016/j.molcel.2022.10.022.Peer-Reviewed Original ResearchConceptsGene expression heterogeneityMurine embryonic stem cellsCell statesGeneration of diverse cell typesExpression heterogeneityCell-type identityDiverse cell typesEmbryonic stem cell stateChromatin programmingStem cell stateTranscribed enhancersDevelopmental robustnessTranscription factor KLF4Expressed genesTranscription processDampened variationsGene expressionEmbryonic stem cellsGenesRegulatory programsPositive feedback networkCell typesZfp281CO bindingKinetics of switching
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