Transcription factor antagonism regulates heterogeneity in embryonic stem cell states
Hu S, Metcalf E, Mahat D, Chan L, Sohal N, Chakraborty M, Hamilton M, Singh A, Singh A, Lees J, Sharp P, Garg S. Transcription factor antagonism regulates heterogeneity in embryonic stem cell states. Molecular Cell 2022, 82: 4410-4427.e12. PMID: 36356583, PMCID: PMC9722640, DOI: 10.1016/j.molcel.2022.10.022.Peer-Reviewed Original ResearchConceptsGene expression heterogeneityMurine embryonic stem cellsCell statesGeneration of diverse cell typesExpression heterogeneityCell-type identityDiverse cell typesEmbryonic stem cell stateChromatin programmingStem cell stateTranscribed enhancersDevelopmental robustnessTranscription factor KLF4Expressed genesTranscription processDampened variationsGene expressionEmbryonic stem cellsGenesRegulatory programsPositive feedback networkCell typesZfp281CO bindingKinetics of switching
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