Improving the decision-making process in the structural modification of drug candidates: enhancing metabolic stability
Nassar A, Kamel A, Clarimont C. Improving the decision-making process in the structural modification of drug candidates: enhancing metabolic stability. Drug Discovery Today 2004, 9: 1020-1028. PMID: 15574318, DOI: 10.1016/s1359-6446(04)03280-5.Peer-Reviewed Original ResearchConceptsStructural modification of drug candidatesDrug candidatesDesign of drug candidatesStructural modificationsDrug discovery processADME propertiesADME studiesMetabolite characterizationBalance of propertiesDecision-making processDrug designMetabolic stabilityDrug discoveryDiscovery processADMEMetabolic instabilityDesignDevelopment stageProperties
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