FTY720 attenuates behavioral deficits in a murine model of systemic lupus erythematosus
Shi D, Tian T, Yao S, Cao K, Zhu X, Zhang M, Wen S, Li L, Shi M, Zhou H. FTY720 attenuates behavioral deficits in a murine model of systemic lupus erythematosus. Brain Behavior And Immunity 2018, 70: 293-304. PMID: 29548997, DOI: 10.1016/j.bbi.2018.03.009.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusOral administration of FTY720Administration of FTY720Blood-brain barrierCentral nervous systemDepression-like behaviorLupus erythematosusInduce neuropsychiatric disordersMurine model of systemic lupus erythematosusModel of systemic lupus erythematosusTherapeutic strategiesInfiltration of T cellsEffective new therapeutic strategiesLevels of adhesion moleculesTreated with oral administrationT cell recruitmentLevels of inflammatory cytokinesBehavioral deficitsNeuropsychiatric disordersImpact patient qualityCerebral endothelial cellsExpression levels of adhesion moleculesCorticosteroid administrationAlbumin levelsLymph nodes
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