2025
A virtual screening strategy to repurpose antifolate compounds as W. b ancrofti DHFR inhibitors
Kwarteng S, Wilhelm J, Salama M, Salama M, Hollander K, Anderson K, Goodey N, Frey K. A virtual screening strategy to repurpose antifolate compounds as W. b ancrofti DHFR inhibitors. Bioorganic & Medicinal Chemistry Letters 2025, 129: 130370. PMID: 40812516, DOI: 10.1016/j.bmcl.2025.130370.Peer-Reviewed Original ResearchConceptsVirtual screening workflowScreening workflowVirtual screening strategyHigh-resolution structuresLow micromolar activityHydrogen bondsDocking scoreDrug discovery effortsCrystallographic studiesNanomolar activityMicromolar activityProtein Data BankBinding interactionsDHFR inhibitorsCompoundsDHFR enzymeDiscovery effortsStructural dataAntifolate compoundsDihydrofolate reductaseBinding sitesFolate binding siteBondsData BankGlu32
2013
Utilizing protein structure to identify non-random somatic mutations
Ryslik GA, Cheng Y, Cheung KH, Modis Y, Zhao H. Utilizing protein structure to identify non-random somatic mutations. BMC Bioinformatics 2013, 14: 190. PMID: 23758891, PMCID: PMC3691676, DOI: 10.1186/1471-2105-14-190.Peer-Reviewed Original ResearchConceptsProtein Data BankProtein structureSomatic mutationsTertiary structureDimensional protein structureProtein tertiary structureTertiary protein structureDriver mutationsMutation clustersTumor suppressorProteinMutational clusteringPharmacological successMutationsCancer proteinsNovel clusterMutational clustersOncogeneSingle strandsR packageData BankCurrent methodologiesGenomeEIF2AK2Suppressor
2008
Erratum: Structural basis for the function and inhibition of an influenza virus proton channel
Stouffer A, Acharya R, Salom D, Levine A, Di Costanzo L, Soto C, Tereshko V, Nanda V, Stayrook S, DeGrado W. Erratum: Structural basis for the function and inhibition of an influenza virus proton channel. Nature 2008, 452: 380-380. DOI: 10.1038/nature06845.Peer-Reviewed Original ResearchProtein Data BankData Bank
1989
B-G cDNA clones have multiple small repeats and hybridize to both chicken MHC regions
Kaufman J, Salomonsen J, Skjødt K. B-G cDNA clones have multiple small repeats and hybridize to both chicken MHC regions. Immunogenetics 1989, 30: 440-451. PMID: 2592020, DOI: 10.1007/bf02421176.Peer-Reviewed Original ResearchConceptsCDNA expression libraryNucleotide identityCDNA clonesChicken DNAHomologous transcriptsShort repeatsExpression libraryMultigene familyOligo-dTB-GFusion proteinHomozygous chickensMHC regionSouthern blottingChicken MHCProtein patternsB-G moleculesCongenic strainsClonesSequence mappingSequenceHaplotypesProteinChickenData Bank
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