2017
Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes
Ritter A, Kapnick S, Murugesan S, Schwartzberg P, Griffiths G, Lippincott-Schwartz J. Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: e6585-e6594. PMID: 28716933, PMCID: PMC5559056, DOI: 10.1073/pnas.1710751114.Peer-Reviewed Original ResearchConceptsActin recoveryCD8<sup>+</sup> cytotoxic T lymphocytesGranule secretionImmunological synapseDepolymerization of actinLytic granule secretionCortical actin densityPhosphatidylinositol 4,5-bisphosphateCytotoxic T lymphocytesTotal internal reflection fluorescenceCortical actinActin clearanceGranule fusionActin densityKill multiple targetsImmune synapseActinT lymphocytesLytic granulesSuperresolution microscopyInfected cellsReflection fluorescenceVirally infected cellsSynapseCytotoxic granules
2013
Hedgehog Signaling Controls T Cell Killing at the Immunological Synapse
de la Roche M, Ritter A, Angus K, Dinsmore C, Earnshaw C, Reiter J, Griffiths G. Hedgehog Signaling Controls T Cell Killing at the Immunological Synapse. Science 2013, 342: 1247-1250. PMID: 24311692, PMCID: PMC4022134, DOI: 10.1126/science.1244689.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesCell PolarityCells, CulturedCentrosomeCytotoxicity, ImmunologicHedgehog ProteinsImmunological SynapsesKruppel-Like Transcription FactorsMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicModels, ImmunologicalNeuropeptidesPatched Receptorsrac1 GTP-Binding ProteinReceptors, Antigen, T-CellReceptors, Cell SurfaceReceptors, G-Protein-CoupledSignal TransductionSmoothened ReceptorT-Lymphocytes, CytotoxicZinc Finger Protein GLI1ConceptsCytotoxic T lymphocytesHh signalingImmunological synapseVertebrate Hedgehog (Hh) signalingPlasma membraneHedgehog (Hh) signalingHh pathway activationT cell receptor activationCytotoxic granulesActin remodelingCentrosome polarizationCytotoxic T lymphocyte functionCytotoxic T lymphocyte killingCilia formationPrimary ciliaT cell killingCentrosome dockingCentrosomeModified ciliumPathway activationGranule releaseNonhematopoietic cellsT lymphocytesReceptor activationCilia
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