O-077 Depletion of MFF from oocytes impairs mitochondrial dynamics, leading to inhibited oocyte maturation and early embryonic development in mice
Hua R, Hai Z, Gu J, Yeung W, Wang T. O-077 Depletion of MFF from oocytes impairs mitochondrial dynamics, leading to inhibited oocyte maturation and early embryonic development in mice. Human Reproduction 2024, 39: deae108.083. DOI: 10.1093/humrep/deae108.083.Peer-Reviewed Original ResearchMitochondrial fission factorEarly embryonic developmentMitochondrial dynamicsGV oocytesOocyte competenceKnockout mouse modelOvulated oocytesOocyte maturationCultured in vitroFemale miceEmbryonic developmentCre-loxP conditional knockout systemMouse modelGerminal vesicleRegulation of mitochondrial dynamicsMethods Female miceIn vitro maturationEmbryo development ratesRegulating mitochondrial dynamicsInhibited oocyte maturationMorphology of mitochondriaEarly embryo developmentPolar body extrusionAbnormal mitochondrial distributionConditional knockout system
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