Omicron SARS-CoV-2 Spike-1 Protein’s Decreased Binding Affinity to α7nAChr: Implications for Autonomic Dysregulation of the Parasympathetic Nervous System and the Cholinergic Anti-Inflammatory Pathway—An In Silico Analysis
Doria D, Santin A, Tuszynski J, Scheim D, Aminpour M. Omicron SARS-CoV-2 Spike-1 Protein’s Decreased Binding Affinity to α7nAChr: Implications for Autonomic Dysregulation of the Parasympathetic Nervous System and the Cholinergic Anti-Inflammatory Pathway—An In Silico Analysis. BioMedInformatics 2022, 2: 553-564. DOI: 10.3390/biomedinformatics2040035.Peer-Reviewed Original ResearchSpike 1 proteinCholinergic anti-inflammatory pathwayAnti-inflammatory pathwayGenetic alterationsParasympathetic nervous systemOmicron infectionCOVID-19 variantsAutonomic dysregulationClinical dataPreclinical resultsNatural immunitySevere formAnimal modelsNervous systemΑ7nAChRTherapeutic antibodiesAttenuation of virulenceCOVID-19InfectionPrevious variantsAttenuated natureOmicronDominant strainAlterationsHumansComparison of infection‐induced and vaccine‐induced immunity against COVID‐19 in patients with cirrhosis
John BV, Doshi A, Ferreira RD, Taddei TH, Kaplan DE, Spector SA, Deng Y, Bastaich D, Dahman B. Comparison of infection‐induced and vaccine‐induced immunity against COVID‐19 in patients with cirrhosis. Hepatology 2022, 77: 186-196. PMID: 35712794, DOI: 10.1002/hep.32619.Peer-Reviewed Original ResearchConceptsPositive SARS-CoV-2 polymerase chain reactionVaccine-induced immunitySARS-CoV-2 infectionInfection-induced immunityImmunity groupsReduced oddsSARS-CoV-2 polymerase chain reactionCOVID-19Retrospective cohort studyCritical COVID-19Multivariable logistic regressionSARS-CoV-2Unvaccinated participantsUnvaccinated patientsFull vaccinationCohort studyCOVID-19 variantsCommunity prevalencePrevious infectionMRNA vaccinesPolymerase chain reactionUS veteransTreatment weightingCirrhosisPropensity score
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