Safety and feasibility of concomitant scalp cooling and limb cryocompression to prevent paclitaxel-induced alopecia and neuropathy
Bandla A, Wong R, Santhanakrishnan P, Magarajah G, Yee Y, Ng W, Ow S, Chan G, Choo J, Lim S, Wong A, Vijayan J, Paxman R, Lee Y, Hui F, Hairom Z, Ang E, Loprinzi C, Thakor N, Lee S, Kumarakulasinghe N, Lim J, Sundar R. Safety and feasibility of concomitant scalp cooling and limb cryocompression to prevent paclitaxel-induced alopecia and neuropathy. Supportive Care In Cancer 2025, 33: 180. PMID: 39937296, PMCID: PMC11821790, DOI: 10.1007/s00520-024-08982-6.Peer-Reviewed Original ResearchConceptsChemotherapy-induced alopeciaChemotherapy-induced peripheral neuropathyScalp coolingHealthy volunteersCancer patientsPrevention of chemotherapy-induced alopeciaCIPN preventionPrevent chemotherapy-induced peripheral neuropathyEORTC QualityWeekly paclitaxel chemotherapyQOL scoresStandard-of-careBody temperature changesCryocompressionCore body temperature changesWeekly paclitaxelCTCAE v4.0Paclitaxel chemotherapyPhysician gradingLimbPatient toleranceAdverse eventsPeripheral neuropathyChemotherapyCryotherapy
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