2020
Updates on molecular and environmental determinants of luteal progesterone production
DeWitt NA, Whirledge S, Kallen AN. Updates on molecular and environmental determinants of luteal progesterone production. Molecular And Cellular Endocrinology 2020, 515: 110930. PMID: 32610113, PMCID: PMC7484338, DOI: 10.1016/j.mce.2020.110930.Peer-Reviewed Original ResearchConceptsProgesterone productionKey sex steroidsLuteal progesterone productionGranulosa cell functionCAMP/PKA pathwayLuteal progesteroneEarly pregnancyGonadotropin stimulationProgesterone levelsSex steroidsHormonal factorsClassic mediatorsCorpus luteumNarrative reviewCritical hormoneSteroid hormonesExogenous environmental chemicalsCell functionEnvironmental chemicalsHormoneRecent evidenceEndogenous hormonesProgesteronePKA pathwayLocal production
2015
The Emerging Role of Angiogenic Factor Dysregulation in the Pathogenesis of Polycystic Ovarian Syndrome
Tal R, Seifer DB, Arici A. The Emerging Role of Angiogenic Factor Dysregulation in the Pathogenesis of Polycystic Ovarian Syndrome. Seminars In Reproductive Medicine 2015, 33: 195-207. PMID: 26036901, DOI: 10.1055/s-0035-1552582.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeGrowth factorOvarian syndromePathophysiology of PCOSAngiogenic factor imbalanceOvarian hyperstimulation syndromeCommon endocrine disorderVascular endothelial growth factorPlatelet-derived growth factorBasic fibroblast growth factorMultiple angiogenic factorsEndothelial growth factorFibroblast growth factorHyperstimulation syndromeOvulatory dysfunctionStromal vascularityAnovulatory infertilityPolycystic ovariesEndocrine disordersReproductive ageTreatment strategiesFollicular growthOvarian angiogenesisAngiogenic factorsCorpus luteum
2002
Caspase-3 Is a Pivotal Mediator of Apoptosis during Regression of the Ovarian Corpus Luteum
Carambula S, Matikainen T, Lynch M, Flavell R, Gonçalves P, Tilly J, Rueda B. Caspase-3 Is a Pivotal Mediator of Apoptosis during Regression of the Ovarian Corpus Luteum. Endocrinology 2002, 143: 1495-1501. DOI: 10.1210/en.143.4.1495.Peer-Reviewed Original ResearchCaspase-3-deficient miceWT miceCorpora luteaCaspase-3Wild-typeLuteal regressionFemale littermatesCaspase-3 enzymePost-ovulationOvarian corpus luteumLevels of progesteroneRate of apoptosisEarly luteal phaseOccurrence of apoptosisAbsence of serumActivated caspase-3Detect activated caspase-3Ex vivo culture experimentsExogenous gonadotropinsNull miceMediators of apoptosisOrgan culture dishesIndividual CLCorpus luteumExecutioners of apoptosis
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