2012
The Carbon Monoxide Releasing Molecule CORM-2 Attenuates Pseudomonas aeruginosa Biofilm Formation
Murray TS, Okegbe C, Gao Y, Kazmierczak BI, Motterlini R, Dietrich LE, Bruscia EM. The Carbon Monoxide Releasing Molecule CORM-2 Attenuates Pseudomonas aeruginosa Biofilm Formation. PLOS ONE 2012, 7: e35499. PMID: 22563385, PMCID: PMC3338523, DOI: 10.1371/journal.pone.0035499.Peer-Reviewed Original ResearchConceptsCORM-2 treatmentP. aeruginosa lung infectionP. aeruginosaAeruginosa lung infectionCORM-2Clinical P. aeruginosaMolecule CORM-2Current antimicrobial agentsChronic infectionLung infectionNew therapiesRelated infectionsNon-mucoid strainsReactive oxygen speciesInfectionNovel therapeutic propertiesTherapeutic propertiesAntimicrobial agentsAdditive effectPseudomonas aeruginosaBiofilm formationOxygen speciesTreatmentAeruginosa
2011
Carbon monoxide-releasing molecule-2 enhances coagulation in rabbit plasma and decreases bleeding time in clopidogrel/aspirin-treated rabbits
Nielsen V, Chawla N, Mangla D, Gomes S, Arkebauer M, Wasko K, Sadacharam K, Vosseller K. Carbon monoxide-releasing molecule-2 enhances coagulation in rabbit plasma and decreases bleeding time in clopidogrel/aspirin-treated rabbits. Blood Coagulation & Fibrinolysis 2011, 22: 756-759. PMID: 22008906, DOI: 10.1097/mbc.0b013e32834c7412.Peer-Reviewed Original ResearchConceptsEar bleeding timeBleeding timeCarbon monoxide-releasing molecule-2CORM-2Plasma in vitroPlasmatic coagulationAdministration of CORM-2Improve coagulationAdministration of clopidogrelDecreased bleeding timeEffects of CORM-2Rabbit plasmaHuman plasma in vitroCoagulation in vitroCarbon monoxide-releasing moleculesEnhancement of coagulationPreclinical investigationsProcoagulant effectRabbit modelIn vivoRabbit plasma in vitroAdministrationPre-ExposureHuman plasmaCoagulation
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