2024
A rare case of childhood-onset systemic lupus erythematosus associated end-stage renal disease with cerebral abscess and hemorrhage
Kim J, Shin J, Kim J, Lee K. A rare case of childhood-onset systemic lupus erythematosus associated end-stage renal disease with cerebral abscess and hemorrhage. Childhood Kidney Diseases 2024, 28: 44-50. DOI: 10.3339/ckd.24.004.Peer-Reviewed Original ResearchChildhood-onset systemic lupus erythematosusEnd-stage renal diseaseSystemic lupus erythematosusCases of childhood-onset systemic lupus erythematosusAcute kidney injuryCentral nervous systemLupus nephritisBrain abscessCerebral abscessLupus erythematosusRare caseCentral nervous system complicationsHigh-dose steroidsChronic autoimmune inflammatory diseaseDaily peritoneal dialysisTreat acute kidney injurySpontaneous cerebral hemorrhageAutoimmune inflammatory diseaseSevere neurological manifestationsImmunosuppressive therapyKidney involvementPeritoneal dialysisControl edemaKidney injuryCerebral infection
2020
Survival of subjects with recurrent glioblastoma receiving intratumoral administration of controlled IL-12 with limited exposure to dexamethasone.
Lukas R, Kurz S, Yu J, Landolfi J, Rao G, Amidei C, Buck J, Hadar N, Estupinan T, Miao J, Loewy J, Wang Y, Demars N, Gelb A, Cooper L. Survival of subjects with recurrent glioblastoma receiving intratumoral administration of controlled IL-12 with limited exposure to dexamethasone. Journal Of Clinical Oncology 2020, 38: 2564-2564. DOI: 10.1200/jco.2020.38.15_suppl.2564.Peer-Reviewed Original ResearchMedian overall survivalImpact of DexIL-12Intratumoral administrationIFN-gGrade III or IV gliomaImmune-mediated anti-tumor effectsLow-dose corticosteroidsAnti-tumor responsesSerum IL-12Time of resectionTumor response dataRecombinant IL-12Survival of subjectsAnti-tumor effectsExposure to dexamethasoneImmune system activationOverall survivalRecurrent glioblastomaIV gliomasControl edemaPreclinical modelsSafety profileInterleukin-12Historical controls
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