Comparative efficacy and safety of trastuzumab biosimilars to the reference drug: a systematic review and meta-analysis of randomized clinical trials
Cargnin S, Shin J, Genazzani A, Nottegar A, Terrazzino S. Comparative efficacy and safety of trastuzumab biosimilars to the reference drug: a systematic review and meta-analysis of randomized clinical trials. Cancer Chemotherapy And Pharmacology 2020, 86: 577-588. PMID: 33005979, DOI: 10.1007/s00280-020-04156-3.Peer-Reviewed Original ResearchConceptsObjective response rateHER2+ breast cancerRandomized Controlled TrialsBreast cancerTrastuzumab biosimilarsMeta-analysisTreatment of HER2+ breast cancerPhase III randomized controlled trialsIntention-to-treat populationMeta-analysis of randomized clinical trialsTreatment-emergent adverse effectsMeta-analysis of randomized controlled trialsRelative riskPurposeTo assess efficacyInfusion-related reactionsPer-protocol populationConclusionThis meta-analysisConfidence intervalsMantel-Haenszel methodMethodsA comprehensive searchRandomized clinical trialsSystematic reviewReference drugOverall survivalNo significant differenceMetformin and colorectal cancer: a systematic review, meta-analysis and meta-regression
Ng C, Jiang A, Toh E, Ng C, Ong Z, Peng S, Tham H, Sundar R, Chong C, Khoo C. Metformin and colorectal cancer: a systematic review, meta-analysis and meta-regression. International Journal Of Colorectal Disease 2020, 35: 1501-1512. PMID: 32592092, DOI: 10.1007/s00384-020-03676-x.Peer-Reviewed Original ResearchConceptsColorectal adenomasCancer incidenceImprove colorectal cancer outcomesNon-metformin usersColorectal cancerIncidence of colorectal adenomasMeta-analysisMetformin usersIncidence of colorectal cancerHazard ratioRisk ratioReducing colorectal adenomasColorectal cancer outcomesCRC-specific survivalCancer survival outcomesEffect of metformin useMetformin useSurvival outcomesAdvanced adenomasDiet-only treatmentDerSimonian and LairdCancer outcomesOverall survivalMethodsA database searchConclusionThis meta-analysis
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