Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix
Akkari L, Gocheva V, Kester J, Hunter K, Quick M, Sevenich L, Wang H, Peters C, Tang L, Klimstra D, Reinheckel T, Joyce J. Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix. Genes & Development 2014, 28: 2134-2150. PMID: 25274726, PMCID: PMC4180975, DOI: 10.1101/gad.249599.114.Peer-Reviewed Original ResearchConceptsCancer cellsCathepsin ZExtracellular matrixInvasion-promoting factorCancer cell-intrinsic functionsArg-Gly-AspTumor microenvironmentCell-intrinsic functionMolecular functionsPromote tumor malignancyProcess of tumor progressionTumor-promoting functionsCellular sourceTumor-promoting factorPancreatic neuroendocrine tumorsNoncancerous cellsNeuroendocrine tumorsCTSZTumor progressionComplexity of interactionsTumor invasionTumor proliferationTumor malignancyCellsTumor
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