2025
Introduction of the transmissible mobile colistin resistance genes mcr-3 and mcr-9 to the USA via imported seafood
Hassan J, Xu T, Osman M, Schiff S, Mann D, Deng X, LeJeune J, Kassem I. Introduction of the transmissible mobile colistin resistance genes mcr-3 and mcr-9 to the USA via imported seafood. MSphere 2025, 10: e00253-25. PMID: 40622135, PMCID: PMC12306178, DOI: 10.1128/msphere.00253-25.Peer-Reviewed Original ResearchConceptsEfficacy of colistinColistin resistance genesColistin resistanceMultidrug-resistant Gram-negative bacteriaMobile colistin resistance geneMobile colistin resistanceIncHI2 plasmidsComplicated infectionsResistance genesMcr-3ColistinLife-threateningAntibiotic resistance genesBacterial infectionsGram-negative bacteriaAntibioticsSeafood samplesGlobal disseminationSeafoodFood animalsInfectionEfficacyPotential carriersGenesIncHI2
2024
Monitoring sewage and effluent water is an effective approach for the detection of the mobile colistin resistance genes (mcr) and associated bacterial hosts in the human population and environment in the USA
Hassan J, Osman M, Xu T, Naas T, Schiff S, Mann D, Esseili M, Deng X, Kassem I. Monitoring sewage and effluent water is an effective approach for the detection of the mobile colistin resistance genes (mcr) and associated bacterial hosts in the human population and environment in the USA. Environmental Pollution 2024, 366: 125515. PMID: 39662581, DOI: 10.1016/j.envpol.2024.125515.Peer-Reviewed Original ResearchWhole-genome sequencingMobile colistin resistance geneColistin resistance genesResistance genesMcr-9Whole-genome sequence analysisKirby-Bauer disk diffusionGram-negative bacterial isolatesBroth micro-dilution assayLast-resort antibioticsTreat recalcitrant infectionsMcr-positive isolatesAntibiotic resistance genesMicro-dilution assayGenome sequenceBacterial hostsHuman populationKirby-BauerIncHI2 plasmidsBiofilm assayBacterial isolatesDisk diffusionMcr-3Water samplesRecalcitrant infections
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