2025
Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis
Schärfen L, Vock I, Simon M, Neugebauer K. Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis. Molecular Cell 2025, 85: 1561-1574.e5. PMID: 40139190, PMCID: PMC12009195, DOI: 10.1016/j.molcel.2025.02.025.Peer-Reviewed Original ResearchConceptsRibosome biogenesisBase pairsNascent pre-mRNACo-transcriptional foldingRNA processing eventsRNA base pairsRDNA lociNascent RNARNA biogenesisRNA polymerasePol IIRRNA nucleotidesNascent chainsPol ICoding PotentialPairing statusPre-mRNAMature mRNABase-paired stateElongating ribosomeFunctional conformationProcessing eventsBiogenesisRibosomeNucleotide
2014
Increasing the Coding Potential of Genomes Through Alternative Splicing: The Case of PARK2 Gene
La Cognata V, Iemmolo R, D’Agata V, Scuderi S, Drago F, Zappia M, Cavallaro S. Increasing the Coding Potential of Genomes Through Alternative Splicing: The Case of PARK2 Gene. Current Genomics 2014, 15: 203-216. PMID: 24955028, PMCID: PMC4064560, DOI: 10.2174/1389202915666140426003342.Peer-Reviewed Original ResearchAlternative splicingTrans-acting mutationsE3 ubiquitin protein ligaseHuman disease genesMultiple protein isoformsUbiquitin-protein ligaseExtensive alternative splicingParkinson protein 2Alternative splice transcriptsHuman Genome ProjectTranscriptomic diversificationProtein diversityCellular lifeIndividual genesWidespread mechanismGenetic regulationProtein ligasePrimary transcriptProtein isoformsSingle geneSplicing featuresGenome ProjectCoding PotentialDisease genesSplicing
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