Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis
Schärfen L, Vock I, Simon M, Neugebauer K. Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis. Molecular Cell 2025, 85: 1561-1574.e5. PMID: 40139190, PMCID: PMC12009195, DOI: 10.1016/j.molcel.2025.02.025.Peer-Reviewed Original ResearchConceptsRibosome biogenesisBase pairsNascent pre-mRNACo-transcriptional foldingRNA processing eventsRNA base pairsRDNA lociNascent RNARNA biogenesisRNA polymerasePol IIRRNA nucleotidesNascent chainsPol ICoding PotentialPairing statusPre-mRNAMature mRNABase-paired stateElongating ribosomeFunctional conformationProcessing eventsBiogenesisRibosomeNucleotide
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