2023
Negative feedback regulation of MAPK signaling is an important driver of chronic lymphocytic leukemia progression
Ecker V, Brandmeier L, Stumpf M, Giansanti P, Moreira A, Pfeuffer L, Fens M, Lu J, Kuster B, Engleitner T, Heidegger S, Rad R, Ringshausen I, Zenz T, Wendtner C, Müschen M, Jellusova J, Ruland J, Buchner M. Negative feedback regulation of MAPK signaling is an important driver of chronic lymphocytic leukemia progression. Cell Reports 2023, 42: 113017. PMID: 37792532, DOI: 10.1016/j.celrep.2023.113017.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinaseChronic lymphocytic leukemiaCLL cellsMitochondrial reactive oxygen speciesChronic lymphocytic leukemia progressionApoptotic cell deathPoor clinical prognosisCLL cell survivalSmall molecule inhibitorsNegative feedback regulationProtein kinaseReactive oxygen speciesMAPK signalingMAPK activityPromising treatment conceptClinical prognosisClinical challengeLymphocytic leukemiaCell survivalAcute activationCell deathDNA damageDUSP6Treatment conceptFeedback regulation
2013
CD84 is a survival receptor for chronic lymphocytic leukemia cells (P2044)
Marom A, Binsky-Ehrenreich I, Sobotta M, Shvidel L, Berrebi A, Hazan-Halevy I, Kay S, Aloshin A, Sagi I, Goldenberg D, Leng L, Bucala R, Herishanu Y, Haran M, Shachar I. CD84 is a survival receptor for chronic lymphocytic leukemia cells (P2044). The Journal Of Immunology 2013, 190: 132.12-132.12. DOI: 10.4049/jimmunol.190.supp.132.12.Peer-Reviewed Original ResearchChronic lymphocytic leukemiaMacrophage migration inhibitory factorBone marrowAbstract Chronic lymphocytic leukemiaChronic lymphocytic leukemia cellsMigration inhibitory factorCLL cell survivalNovel therapeutic strategiesLymphocytic leukemia cellsCD84 expressionPeripheral bloodLymphoid organsMcl-1 expressionClinical trialsLymphocytic leukemiaCLL cellsTherapeutic strategiesB lymphocytesMalignant cellsInhibitory factorInduces cell deathSurvival receptorCD84Leukemia cellsProtein levels
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