Sodium channel activity modulates multiple functions in microglia
Black JA, Liu S, Waxman SG. Sodium channel activity modulates multiple functions in microglia. Glia 2008, 57: 1072-1081. PMID: 19115387, DOI: 10.1002/glia.20830.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsAnimals, NewbornBrainCell MovementCell ProliferationCells, CulturedCoculture TechniquesCytokinesGliosisInflammation MediatorsMicrogliaNAV1.1 Voltage-Gated Sodium ChannelNAV1.5 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelNerve Tissue ProteinsPhagocytosisPhenytoinRatsRats, Sprague-DawleySodium Channel BlockersSodium ChannelsTetrodotoxinConceptsIL-1 betaIL-1 alphaSodium channelsTNF-alphaPhagocytic activitySodium channel blockadeSodium channel Nav1.1Central nervous systemVoltage-gated sodium channelsSodium channel activitySodium channel isoformsActivated microgliaIL-10IL-6MCP-1Microglial migrationChannel Nav1.1Cultured microgliaIL-2IL-4MicroM TTXChannel blockadeMed miceMicrogliaTissue insultMultiple sodium channel isoforms and mitogen‐activated protein kinases are present in painful human neuromas
Black JA, Nikolajsen L, Kroner K, Jensen TS, Waxman SG. Multiple sodium channel isoforms and mitogen‐activated protein kinases are present in painful human neuromas. Annals Of Neurology 2008, 64: 644-653. PMID: 19107992, DOI: 10.1002/ana.21527.Peer-Reviewed Original ResearchConceptsMultiple sodium channel isoformsHuman neuromasSodium channel isoformsPainful neuromasMitogen-activated protein kinaseERK1/2 MAP kinasesNeuronal voltage-gated sodium channelsChannel isoformsSodium channel Nav1.3Sodium channelsSpontaneous ectopic dischargeTreatment of painSodium channel Nav1.1Possible therapeutic targetVoltage-gated sodium channelsMAP kinase p38Ectopic dischargesChronic painTraumatic neuromaChannel Nav1.1MAP kinaseExtracellular signal-regulated kinases 1NeuromaTherapeutic targetPain
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